Barrister-375 is the medicine manufactured with the combination of Amoxicillin Trihydrate IP eq to Amoxycillin and Potassium Clavulanate IP (as Potassium Clavulante Diluted IP) eq to Clavulanic acid


Amoxicillin trihydrate is a medicine which is used to treat certain types of bacterial infections.

Chemistry of Amoxicillin Trihydrate IP

Chemical Formula: C16H19N3O5S-3H2O

Molecular Mass: 419.45

Physical Properties:White to off-white crystalline powder

Solubility: Freely soluble in water

Pharmacodynamics of Amoxicillin Trihydrate IP

The drug Amoxicillin Trihydrate IP acts by restraining the synthesis of bacterial cell walls. It inhibits cross-linkage amid the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria.

Medical uses of Amoxicillin Trihydrate IP

Amoxicillin Trihydrate IP is used to treat:

  • Acute otitis media
  • Streptococcal pharyngitis
  • Pneumonia
  • Skin infections
  • Urinary tract infections
  • Salmonella
  • Lyme disease
  • Chlamydia infections
  • Side effects of Amoxicillin Trihydrate IP

    It could have following minor as well as serious side effects:

  • Diarrhoea
  • Nausea
  • Skin rash or rashes
  • Itching
  • Urticaria
  • Vomiting
  • Colitis
  • Convulsions
  • Feeling dizzy
  • Hyperactivity
  • Jaundice
  • Kidney problems
  • Liver problems
  • Pseudomembran
  • Chest pain
  • Pale skin
  • Feeling like you might pass out
  • Headache
  • Diarrhea or constipation
  • Overdose of Amoxicillin Trihydrate IP

    Though, there is no specific problems of Amoxicillin overdose; however, in case of overdose, symptomatic treatment should be given.

    Cautions of Amoxicillin Trihydrate IP

  • Before taking amoxicillin, it is suggested to tell your medical history to your doctor
  • During pregnancy use amoxicillin with pre-caution and under the surveillance of your doctor

    Clavulanic acid is biosynthetically produced from the amino acid arginine and the sugar glyceraldehyde 3-phosphate.

    Chemistry of Clavulanic Acid IP

    Chemical Formula: C8H9NO5

    Molecular Mass: 199.16 Physical Properties:White crystalline powder

    Solubility: Freely soluble in water

    Pharmacokinetics of Clavulanic Acid IP

    Absorption: Combining clavulanate potassium with amoxicillin widens the antibacterial spectrum of amoxicillin to include numerous bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.

    Distribution: Clavulanic Acid distributes readily into most body tissues and fluids except the brain and spinal fluid.

    Elimination: About 50-70% of amoxicillin and 25-40% of clavulanic acid are excreted unchanged in urine during the time period of 1st 6 hours after admin.

    Pharmacodynamics of Clavulanic Acid IP

    Clavulanic Acid is used to prevail over resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. In its most widespread form, the potassium salt potassium clavulanate is combined with amoxicillin.

    Cautions of Clavulanic Acid IP

    Before taking amoxicillin, it is suggested to tell your medical history to your doctor.