Corflam (Ibuprofen &Paracetamol)

Corflam is the product of Ibuprofen &Paracetamol.


Formula - C13 H11O2

Molecular Weight - 206

Physical Properties of Ibuprofen:

  • Ibuprofen is tasteless, white power or crystals
  • Solubility: Practically insoluble in water but soluble in alcohol and chloroform, and also soluble in alkaline solutions.

    Absorption: Ibuprofen is absorbed from the gastrointestinal tract

    Distribution: After oral administration, peak plasma concentrations are observed within 1-2 hours. The plasma half-life is about 2 hours and the plasma protein binding is as high as 99%.

    Metabolism: Greater than 90% of the injected dose is metabolised and gets converted into metabolites or their conjugates.

    Elimination: Ibuprofen is excreted as metabolite in the urine. Its excretion is rapid.


    Ibuprofen is an anti-inflammatory and very weak analgesic drug. It is a propionic acid derivative. Ibuprofen is the first member of phenyl propionic acid derivative group. It is an effective inhibitor of cyclo- oxygenase, an enzyme responsible for the prostaglandin bio-synthesis.


    Formula – C8 H9No2

    Molecular Weight –151.2

    Physical Properties of Paracetamol:

  • Paracetamol is white odourless crystalline powder.
  • Solubility: Practically soluble in water.

    Absorption: It is readily get absorbed from the g.i. tract. Peak plasma concentration is achieved in 30 minutes 2 hours. It is excreted through kidney, mainly as glucuronide and sulphate.


    Paracetamol has analgesic and antipyretic effects. Which do not differ significantly from those of aspirin. It is also very weak anti-inflammatory effect.


    Corflam is being used to treat various problems such as:

  • Frozen shoulder syndrome: A degenerative condition. Corflam can be given as co-prescription.
  • Dysmenorrhoea: the role of prostaglandins is now established in dysmenorrhoea. Ibuprofen is a powerful prostaglandin inhibitor and paracetamol, besides being a safe analgesic, does not alter the blood clotting time, unlike aspirin – like drugs.
  • Inflammatory condition in Urology Opthalmology, ENT cases, Post-surgical inflammation: In such condition, Corflam gives prompt relief because of its anti – inflammatory analgesic properties.

    Corflam should be given with care to patients having bleeding disorders, peptic ulcer and liver or kidney damage. Further, Corflamshould be prescribed with care to the patients with cardiovascular disease and to the patients who have developed asthma with any other NSAID.

    If possible then it is advisable not to prescribe Corflam during pregnancy.


    The most frequent side effects occurring with Ibuprofen are G.I. disturbances. Though, the Ibuprofen is safe and well tolerated drug as far as g.i. problems are concerned, compared to other anti-inflammatory drugs, such effects cannot be totally ruled out. Other reactions include skin rashes, nervousness, drowsiness, blurred vision etc.


    Overdose of Ibuprofen and high amount of Paracetamol may couse depressed consciousness, hypotension, gastric irritation and slightly impaired vision. Howeve, in such condition, the best therapy is to remove the undigested drug, to wash mucosal membrane of the g.i. tract and to provide symptomatic supportive therapy.