Paracetamol is a medicine more commonly used over-the-counter analgesic (i.e. for pain reliever) and antipyretic (i.e. for fever reducer).

Chemistry of Paracetamol

Chemical Formula: C8H9NO2

Molecular Mass: 151.17 g/mol

Pharmacokinetics of Paracetamol

Absorption: Paracetamol is easily absorbed from the gastrointestinal tract with peak plasma concentrations occurring nearby 10 to 60 minutes after the oral administration.

Distribution: Paracetamol is distributed into most of the body tissues. Plasma protein binding is negligible at usual therapeutic doses but increases with increasing doses.

Elimination: Its elimination half-life varies between 1 and 3 hours.

Pharmacodynamics of Paracetamol

Paracetamol is a p-aminophenol derivative that exposes analgesic and antipyretic activity and it does not have anti-inflammatory activity.

Medical uses of Paracetamol

Paracetamol has the following medical uses:

  • Used to reduce fever in people of all ages
  • Used for the relief of pains associated with various parts of the body
  • Side Effects of Paracetamol

    Though, the side effects of Paracetamol are mild to non-existent but prolonged daily use may cause:

  • Upper gastrointestinal complications (i.e. stomach bleeding)
  • Kidney or liver damage
  • Occasionally, it causes skin rashes and hypersensitivity reactions.
  • Overdose of Paracetamol

    Though, signs and symptoms of Paracetamol toxicity initially might be absent or vague but if treatment of overdose has not been given then it can cause to liver failure and death within days.

    Caution of Paracetamol

    Paracetamol should be used with caution especially with the patients who have:

  • Impaired renal function
  • Impaired hepatic function