Fenace-P is the medicine prepared with the combination of Dicyclomine HCL IP & Paracetamol IP.

Dicyclomine HCL IP

Dicyclomine is an anticholinergic in nature and it blocks muscarinic receptors.

Chemistry of Dicyclomine HCL IP

Chemical Formula: C19H35NO2, HCl

Molecular Mass: 309.487g/mol

Physical Properties: White, odourless, and crystalline powder

Solubility: Soluble in water and also soluble in ethanol and in chloroform

Pharmacokinetics of Dicyclomine HCL IP

Absorption: Rapidly absorbed from the GI tract and reaches peak plasma concentrations (Maximum Time range between 60 to 90 min).

Distribution: the Volume of distribution is about 3.65 L/kg.

Elimination: 79.5% excreted in the urine and 8.4% in feces.

Pharmacodynamics Dicyclomine HCL IP

Dicyclomine is an anticholinergic medicine that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle.

Medical uses of Dicyclomine HCL IP

Dicyclomine has the following medical uses:

  • Used to treat intestinal hypermotility, (especially during the Irritable Bowel Syndrome, IBS)
  • Used in diarrhea, and biliary dyskinesia
  • Used for the muscle spasms and cramping in the gastrointestinal tract
  • It is a smooth muscle relaxant
  • Side Effects of Dicyclomine HCL IP

    Dicyclomine may cause range of anticholinergic side effects such as:

  • Vomiting
  • Stomach problem
  • Dryness of your mouth
  • Gas or bloating
  • Loss of appetite
  • Dizziness
  • Headache
  • Weakness
  • Double vision
  • Difficulty in urination
  • Confusion
  • Forgetfulness
  • Anxiety
  • Tiredness
  • Rapid heartbeat
  • Itching
  • Overdose of Dicyclomine HCL IP

    The symptom of overdose of Dicyclomine may be severe or may be minor; however, in any case you are needed to take precaution and consult your doctor. Some of the symptoms of overdose are:

  • Headache
  • Stomach problem
  • Nausea
  • Vision problem
  • Dizziness
  • Dry mouth
  • Nervousness
  • Caution of Dicyclomine HCL IP

    While using this Dicyclomine Hydrochloride breastfeeding is not recommended.


    Paracetamol is a medicine more commonly used over-the-counter analgesic (i.e. for pain reliever) and antipyretic (i.e. for fever reducer).

    Chemistry of Paracetamol

    Chemical Formula: C8H9NO2

    Molecular Mass: 151.17 g/mol

    Pharmacokinetics of Paracetamol

    Absorption: Paracetamol is easily absorbed from the gastrointestinal tract with peak plasma concentrations occurring nearby 10 to 60 minutes after the oral administration.

    Distribution: Paracetamol is distributed into most of the body tissues. Plasma protein binding is negligible at usual therapeutic doses but increases with increasing doses.

    Elimination: Its elimination half-life varies between 1 and 3 hours.

    Pharmacodynamics of Paracetamol

    Paracetamol is a p-aminophenol derivative that exposes analgesic and antipyretic activity and it does not have anti-inflammatory activity.

    Medical uses of Paracetamol

    Paracetamol has the following medical uses:

  • Used to reduce fever in people of all ages
  • Used for the relief of pains associated with various parts of the body
  • Side Effects of Paracetamol

    Though, the side effects of Paracetamol are mild to non-existent but prolonged daily use may cause:

  • Upper gastrointestinal complications (i.e. stomach bleeding)
  • Kidney or liver damage
  • Occasionally, it causes skin rashes and hypersensitivity reactions.
  • Overdose of Paracetamol

    Though, signs and symptoms of Paracetamol toxicity initially might be absent or vague but if treatment of overdose has not been given then it can cause to liver failure and death within days.

    Caution of Paracetamol

    Paracetamol should be used with caution especially with the patients who have:

  • Impaired renal function
  • Impaired hepatic function