Fenac-S is the drug manufactured with the combination of Diclofenac Potassium BP and Serratiopeptidase.

Diclofenac Potassium BP

Diclofenac potassium is a pain-relief drug that is normally used to treat symptoms of osteoarthritis or rheumatoid arthritis, painful menstrual periods, and for inflammation, swelling, and/or stiffness caused by several conditions.

Chemistry of Diclofenac Potassium

Chemical Formula: C14H10Cl2KNO2

Molecular Mass: 334.25

Physical Properties: Diclofenac Potassium is a slightly yellowish white to light beige, practically odorless, somewhat hygroscopic crystalline powder.

Solubility: Freely soluble in methanol, soluble in water and ethanol, and practically insoluble in chloroform.

Pharmacokinetics of Diclofenac Potassium

Absorption: Generally, Diclofenac Potassium is 100% absorbed after oral administration compared to IV administration as measured by urine recovery.

Distribution: The noticeable volume of distribution (V/F) of diclofenac potassium is 1.3 L/kg.

Elimination: Diclofenac Potassium is eliminated through metabolism and succeeding urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites.\

Pharmacodynamics of Diclofenac Potassium

Diclofenac Potassium drugs are a non-steroidal anti-inflammatory drug (NSAID) that reveals anti-inflammatory, analgesic, and antipyretic activities in animals. The mechanism of action of diclofenac potassium drugs is little understood but might be related to prostaglandin synthetase inhibition.

Medical uses of Diclofenac Potassium

Diclofenac Potassium has following medical use:

  • For the treatment of primary dysmenorrhea
  • For the treatment of mild to moderate pain
  • For the relief from the signs and symptoms of osteoarthritis
  • For the relief from the signs and symptoms of rheumatoid arthritis
  • Side effects of Diclofenac Potassium

    It could have following minor as well as serious side effects:

  • Abdominal pain
  • Constipation
  • Diarrhea
  • Heartburn or indigestion (dyspepsia)
  • Gas
  • Overdose of Diclofenac Potassium

    Overdose of Diclofenac Potassium may cause:

  • Lethargy
  • Drowsiness
  • Nausea
  • Epigastric Pain
  • Gastrointestinal bleeding can occur
  • Cautions of Diclofenac Potassium

    Diclofenac Potassium tablets cannot be expected as replacement for corticosteroids or to treat corticosteroid insufficiency. Sudden discontinuation of corticosteroids may cause disease exacerbation.


    Serratiopeptidase is the drug widely used for the treatment of acute pain.

    Pharmacokinetics of Serratiopeptidase

    The drug Serratiopeptidase passes through stomach in unchanged form and is absorbed in the intestine. Serratiopeptidase is detected in urine as insignificant quantity.

    Pharmacodynamics of Serratiopeptidase

    The drug Serratiopeptidase works by improving aggravated circulation in the inflammatory focus by breaking down unusual exudates and protein by encouraging the absorption of the putrid products through the blood and lymphatic vessels.

    Serratiopeptidase tablets also facilitate the elimination of sputum, pus and haematoma. It is done by breaking down the liquefying mucus secretions and fibrin clots.

    Medical uses of Serratiopeptidase

    Serratiopeptidase has following medical use:

  • Chronic inflammation
  • Headaches, muscle and joint pain
  • Serious diseases like cancer and heart disease
  • Back pain
  • Superficial thrombophlebitis
  • Postoperative & traumatic swelling
  • Acute or chronic ear, nose or throat disorder
  • Side effects of Serratiopeptidase

    It could have following minor as well as serious side effects:

  • Anorexia
  • Gastric Discomfort
  • Nausea
  • Overdose of Serratiopeptidase

    Overdose of Serratiopeptidase may cause:

  • Nausea
  • Vomiting
  • Anorexia
  • Epigastric Discomfort
  • Cautions of Serratiopeptidase

    In case of severe liver and kidneys diseases the Serratiopeptidase should be used carefully.