Montello is the medicine manufactured with the combination of Montelukast Sodium IP Eq to Montelukast and Levocetirizine Di-hydrochloride IP. Montello is manufactured for the both – adult and kid by increasing and decreasing the power (generally used in mg).

Montelukast Sodium

Montelukast sodium is medicine generally used for long-term prevention from the disease asthma.

Chemistry of Montelukast Sodium

Chemical Formula: C35H35ClNNaO3S

Molecular Mass: 608.18

Physical Properties: white to off-white powder

Solubility: Montelukast sodium is freely soluble in methanol, ethanol, and water and practically insoluble in acetonitrile.

Pharmacokinetics of Montelukast Sodium

Absorption: After the oral administration, Montelukast is rapidly absorbed.

Distribution: Montelukast is about 99% bound to plasma proteins and its steady state volume of distribution is range between 8 and 11 liters.

Elimination: The plasma clearance of Montelukast averages 45 mL/min in healthy adults and about 86% of the radioactivity used to recovere in 5-day fecal collections and <0.2% recovere in urine.

In various studies, it is found that the mean plasma half-life of montelukast in healthy young adults range from 2.7 to 5.5 hours.

PPharmacodynamics of Montelukast Sodium

Montelukast Sodium causes inhibition of airway cysteinyl leukotriene receptors as confirmed by the capacity to inhibit bronchoconstriction due to inhaled LTD4 in asthmatics. Furthermore, the doses as low as 5 mg cause substantial blockage of LTD4 -induced bronchoconstriction; so, in a placebo-controlled, crossover study, inhibited early- and late-phase bronchoconstriction due to antigen challenge by 75% and 57%, accordingly.

Medical uses of Montelukast Sodium

Montelukast Sodium has following medical use:

  • Asthma
  • Exercise induced Bronchospasm
  • Allergic Rhinitis
  • Urticaria
  • Side effects of Montelukast Sodium

    Montelukast Sodium has following side effects:

  • Headaches
  • Abdominal pain
  • Abnormal dreams
  • Drowsiness
  • Insomnia
  • Nausea
  • Hypersensitivity reactions
  • Heartburn
  • Infections
  • Muscle aches
  • Overdose of Montelukast Sodium

    There are following symptoms of Montelukast Sodium overdose:

  • Abdominal pain
  • Somnolence
  • Thirst
  • Headache
  • Vomiting
  • Psychomotor hyperactivity
  • Cautions of Montelukast Sodium

    Since Montelukast Sodium is hypersensitive hence, if it cause any sort of problem including feeling of pins and needles, numbness of extremities, flu-like symptoms, rash, sinusitis then patient need to inform immediately to the respective doctor. Furthermore, do not use it to get relief from the acute bronchospasm.

    Levocetirizine Dihydrochloride

    Levocetirizine Dihydrochloride is a drug that is used for the treatment and management of symptoms related to allergies.

    Chemistry of Levocetirizine Dihydrochloride

    Chemical Formula: C21H25ClN2O3.2(HCl)

    Molecular Mass: 461.81

    Physical Properties: White crystalline powder

    Solubility: Soluble in water

    Pharmacokinetics of Levocetirizine Dihydrochloride

    Absorption: Rapidly and extensively absorbed and steady state achieved after 2 days.

    Distribution: Plasma protein binding is about 92%. Vd is about 0.4 L/kg.

    Metabolism: Metabolism is less than 14% and by aromatic oxidation.

    Elimination: The half-life is between 8 and 9 hours and the elimination is 85.4% and 12.9% through urine and feces, respectively.

    Pharmacodynamics of Levocetirizine Dihydrochloride

    Levocetirizine Dihydrochloride medicines are formulated as immediate discharge; white, film-coated, oval-shaped tablets manufactured especially for oral administration. Its inactive ingredients are: microcrystalline cellulose, colloidal anhydrous silica, lactose monohydrate, and magnesium stearate.

    Medical uses of Levocetirizine Dihydrochloride

    Levocetirizine Dihydrochloride has following medical use:

  • Used for seasonal and perennial allergic rhinitis
  • Used for the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria
  • Side effects of Levocetirizine Dihydrochloride

    Though, Levocetirizine dihydrochloride is well tolerated; however, it could have following minor as well as serious side effects:

  • Severe drowsiness that interferes with your daily activities
  • Sign of an allergic reaction (such as unexplained rash, itching, hives, and unexplained swelling; generally over the lips, mouth, or throat
  • Overdose of Levocetirizine Dihydrochloride

    There are following symptoms of Levocetirizine dihydrochloride overdose:

  • Agitation
  • Restlessness
  • Drowsiness
  • Cautions of Levocetirizine Dihydrochloride

    Do not take Levocetirizine Dihydrochloride if you have had an allergic reaction of this drug and also it is not suggested to take alcohol or use medicines that may cause drowsiness while you are taking Levocetirizine Dihydrochloride.