Probicof Syrup

Probicof Syrup is the drug manufactured with the combination of Ambroxol HCL IP, Terbutaline sulphate IP, Guaiphenesin IP, and Menthol IP.

Ambroxol HCL IP

Ambroxol is a secretolytic instrument used for the treatment of respiratory diseases associated with viscid or excessive mucus.

Chemistry of Ambroxol HCL IP

Chemical Formula: C13H18Br2N2O•HCl

Molecular Mass: 414.57

Physical Properties: Yellow to yellowish crystalline powder

Solubility: Freely soluble in water

Pharmacokinetics of Ambroxol HCL IP

Absorption: Ambroxol administered orally is approximately 70-80% and it is rapidly absorbed after oral administration.

Distribution: The distribution half-life of ambroxol is about 1.3 hours.

Elimination: Elimination of ambroxol is biphasic, with a half-life of 1.3 hours and a half-life of 8.8 hours. Excretion is primarily by the kidneys and about 5-6% of a dose is excreted unchanged in the urine.

Pharmacodynamics of Ambroxol HCL IP

Ambroxol is an active N-desmethyl metabolite of the mucolytic bromhexine. It may enhance the quantity and diminish the viscosity of tracheobronchial secretions. It may also act as an expectorant, rising mucocliary transport via stimulation of cilliary motility.

Furthermore, Ambroxol may kindle the synthesis and secretion of pulmonary surfactant; the drug has been referred to as a "surfactant activator."

Medical uses of Ambroxol HCL IP

Ambroxol HCL is used to treat:

  • Bronchitis
  • Chronic bronchitis
  • Cystic fibrosis
  • Chronic respiratory tract disease
  • Spasmodic stenosis
  • Side effects of Ambroxol HCL IP

    It could have following side effects:

  • Hypersensitivity reactions
  • Contact allergy
  • Nausea
  • Headache
  • Gastrointestinal disorder
  • Overdose of Ambroxol HCL IP

    Though, there is no specific symptoms of overdose have been reported; however, if it occurs then symptomatic treatment should be provided.

    Cautions of Ambroxol HCL IP

    Ambroxol HCl should be given cautiously to the patients suffering from gastric ulceration.

    Terbutaline Sulphate IP

    Terbutaline sulfate is a drug used for the treatment of asthma and emphysema.

    Chemistry of Terbutaline sulphate

    Chemical Formula: C12H19NO3

    Molecular Mass: 225.284

    Physical Properties: white crystalline powder

    Solubility: Freely soluble in water

    Pharmacokinetics of Terbutaline sulphate

    Absorption: About 30-50% if administered orally and well absorbed subcutaneously.

    Elimination: Approx 90% of the drug is excreted in the urine, 96 hours after subcutaneous administration.

    Pharmacodynamics of Terbutaline sulphate

    Terbutaline is a comparatively selective beta2-adrenergic bronchodilator that has tiny or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on beta2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than moderately selective beta2-agonists. Terbutaline sulphate relaxes smooth muscle and restrains uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation.

    Medical uses of Terbutaline sulphate

    Ambroxol HCL is used to treat:

  • Bronchospasm
  • Obstructive airway disease
  • Also used acute IV and sub-Q therapy in particular women to restrain uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial
  • Side effects of Terbutaline sulphate

    It could have following side effects:

  • It can cause cardiovascular effects
  • Dizziness
  • Palpitations
  • Overdose of Terbutaline sulphate

    Symptoms of Terbutaline overdose are:

  • Seizures
  • Chest pain
  • High blood pressure (hypertension)
  • Low blood pressure (hypotension)
  • Irregular heart rhythms (arrhythmias)
  • Nervousness
  • Dizziness
  • Fatigue
  • Insomnia
  • Cautions of Terbutaline sulphate

    It should be used with caution with patients of:

  • Sympathomimetic amines
  • Cardiovascular disorders
  • Hypertension
  • Cardiac arrhythmias
  • The pregnant women also need take precaution before using Terbutaline sulphate.

    Guaiphenesin IP

    Guaifenesin is a drug usually taken orally to assist the bringing up of phlegm from the airways in acute respiratory tract infections.

    Chemistry of Guaifenesin IP

    Chemical Formula: C10H14O4

    Molecular Mass: 198.216 g/mol

    Pharmacokinetics of Guaifenesin IP

    Guaiphenesin is well absorbed from the gastrointestinal tract and it is metabolised largely to Beta-2-methoxyphenoxy-lactic acid and then excreted in the urine. The plasma half life of guaiphenesin is about one hour.

    Pharmacodynamics of Guaifenesin IP

    Guaiphenesin is a medicine which treats chest congestion by loosening and dropping the viscosity of phlegm, escalating the volume of phlegm and making coughs more productive.