Tagrid-O is the drug composed of Ofloxacin IP & Ornidazole IP.


Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone medicine category and it isconsidered to be a second-generation fluoroquinolone.

Chemistry of Ofloxacin IP

Chemical Formula: C18H20FN3O4

Molecular Mass: 361.38

Pharmacokinetics of Ofloxacin IP

After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 μg/mL and 3.6 μg/mL, correspondingly, are forecasted at steady-state.

Distribution: In vitro, about 32% of the drug in plasma is protein bound and floxin is extensively distributed to body tissues. Ofloxacin has been detected in blister fluid, cervix, ovary, skin, prostatic fluid, lung tissue, prostatic tissue, and sputum. Pyridobenzoxazine ring appears to decrease the extent of parent compound metabolism.

Elimination: Less than 5% is eliminated by the kidneys as desmethyl or N-oxide metabolites; 4% to 8% by feces.

Pharmacodynamics of Ofloxacin IP

Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by restraining DNA gyrase, a sort of II topoisomerase, and topoisomerase IV. It is an enzyme essential to separate replicated DNA, thus inhibiting bacterial cell division.

Medical uses of Ofloxacin IP

Ofloxacin has following medical use:

  • Acute bacterial exacerbations of chronic bronchitis
  • Acute pelvic inflammatory disease
  • Uncomplicated skin and skin structure infections
  • Nongonococcal urethritis and cervicitis
  • Community-acquired pneumonia
  • Mixed Infections of the urethra and cervix
  • Uncomplicated cystitis
  • Prostatitis
  • Acute, uncomplicated urethral and cervical gonorrhoea
  • Complicated urinary tract infections
  • Side effects of Ofloxacin IP

    Ofloxacin could have following side effects:

  • Sleep problems
  • Headache
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhea
  • Itching
  • External genital itching in women
  • Vaginal inflammation (vaginitis)
  • Taste changes
  • Overdose of Ofloxacin IP

    Overdose of Ofloxacin may cause:

  • Central nervous system toxicity
  • Cardiovascular toxicity
  • Tendon/articular toxicity
  • Hepatic toxicity
  • Renal failure and seizure
  • Cautions of Ofloxacin IP

    The patients who are being treated with Ofloxacin should not expose themselves unreasonably to strong sunlight and also should avoid UV rays.


    Ornidazole is a drug that cures some protozoan infections.

    Chemistry of Ornidazole

    CChemical Formula: C7H10ClN3O3

    Molecular Mass: 219.63

    Physical Properties: It is white or slightly yellow piece

    Pharmacokinetics of Ornidazole

    Absorption: Ornidazole is easily absorbed from the GIT and peak plasma concentrations of approximately 30 mcg/ml and are achieved within 2 hours of a single dose of 1.5 g.

    Distribution: It is extensively distributed in body tissues and fluids, including cerebrospinal fluid. More than 90% of Ornidazole dose is metabolized in liver.

    Elimination: The elimination half-life (t1/2) of Ornidazole is between 12 and 14 hours and it is excreted in the urine and to a lesser extent in the faeces.

    Pharmacodynamics of Ornidazole

    After the passive absorption into bacterium cell, the nitro group of Ornidazole is transformed to amine group by ferrodoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the essential component of microorganism killing for Ornidazole. The method of action is alike in protozoa.

    MMedical uses of Ornidazole

    Ornidazole has following medical use:

  • Anaerobic infections both pre & post operatively
  • Amoebic dysentery
  • Amoebic liver abscess
  • Bacterial vaginosis
  • Hepatic and intestinal amoebiasis
  • Some other protozoan infection including Giardiasis and Trichomoniasis
  • Side effects of Ornidazole

    Ornidazole could have following side effects:

  • Diarrhea
  • Drowsiness
  • Nausea
  • Sleeping Problems
  • Abnormal metallic taste
  • Headache
  • Overdose of Ornidazole

    Overdose of Ofloxacin may cause:

  • Confusion
  • Dizziness
  • Impairment of consciousness
  • Convulsive seizures
  • Gastrointestinal reactions
  • Cautions of Ornidazole

    Hypersensitive people are not suggested to use Ornidazole.